Editorial: The Post-Exome Era

author

  • Mina Ohadi Genetic Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
Abstract:

The Iranian Rehabilitation Journal (IRJ) invites research papers on the genetic basis of single gene and complex disorders. This vastly dynamic branch of science will complement the multidisciplinary wealth of expertise in the fields of social welfare and rehabilitation. The past few years have witnessed outstanding research projects on the genetic causes of numerous debilitating disorders, such as intellectual disability, deafness, and blindness. Those achievements are largely indebted to the next generation exome sequencing technologies. Exome sequencing detects variants in coding exons, and can expand the target to include untranslated regions (UTRs) and microRNA to present a more comprehensive view of gene regulation. Whole-exome sequencing (WES) determines variations of all coding regions, or exons, of known genes. Once beyond imagination and reach, WES promises to revolutionize the perspective of a wide range of applications, including population genetics, medical genetics, and cancer studies.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Editorial—The Last Post

Editorial ? The Last Post Sad news and hard luck stories abound in times of financial stringency and I am sorry to add the plight of the West of England Medical Journal to the list of woes. With the last issue of the journal we asked whether or not recipients would be willing to pay ?20 per annum to receive four quarterly issues of the journal. Unfortunately despite circularising 4,000 doctors ...

full text

Editorial: The Era of the Outcome Measure

T he short history of hearing aid fitting can be divided into three eras . The first era, from roughly 1946 to about 1970, might be described as the era of the PB list. A fitting was successful when the aided speech recognition score for single-syllable words was optimized. The second era, from the 1970s to the present, might be described as the era of the engineering solution . A fitting was s...

full text

Editorial Human epididymis protein 4 : the start of a post - ROMAn era ?

As the result of advances in the understanding of molecular bases of cancer and introduction of targeted therapy, laboratory medicine currently plays an indispensable role in the management of cancer patients (1) . Traditionally, the measurement of tumor markers has been a topic of major interest for both medical oncology and clinical chemistry/laboratory medicine. With time the well-establishe...

full text

Tuberculosis drug discovery in the post-post-genomic era

The expectation that genomics would result in new therapeutic interventions for infectious diseases remains unfulfilled. In the post-genomic era, the decade immediately following the availability of the genome sequence of Mycobacterium tuberculosis, tuberculosis (TB) drug discovery relied heavily on the target-based approach but this proved unsuccessful leading to a return to whole cell screeni...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 14  issue None

pages  3- 4

publication date 2016-03

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023